| 1 | RA CAPITAL MANAGEMENT, L.P. | $18.2M | 4.0M | Hold |
| 2 | BVF INC/IL | $14.8M | 3.2M | Added |
| 3 | ACORN CAPITAL ADVISORS, LLC | $12.9M | 2.8M | Hold |
| 4 | StepStone Group LP | $12.1M | 2.7M | Hold |
| 5 | ADAR1 Capital Management, LLC | $10.2M | 2.2M | Trimmed |
| 6 | Vivo Capital, LLC | $8.8M | 1.9M | Hold |
| 7 | Vestal Point Capital, LP | $8.3M | 1.8M | Trimmed |
| 8 | VANGUARD GROUP INC | $8.1M | 1.8M | Added |
| 9 | BlackRock, Inc. | $6.8M | 1.5M | Added |
| 10 | Trails Edge Capital Partners, LP | $6.6M | 1.4M | New |
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $5.5M | 1.2M | Hold |
| 12 | CITADEL ADVISORS LLC | $5.4M | 1.2M | Added |
| 13 | Sio Capital Management, LLC | $4.9M | 1.1M | Hold |
| 14 | Prosight Management, LP | $4.5M | 978,992 | Trimmed |
| 15 | Logos Global Management LP | $4.4M | 963,855 | New |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | $3.3M | 724,438 | Added |
| 17 | NEA Management Company, LLC | $2.2M | 478,548 | Hold |
| 18 | STATE STREET CORP | $2.1M | 463,662 | Added |
| 19 | Ensign Peak Advisors, Inc | $2.0M | 431,631 | New |
| 20 | RENAISSANCE TECHNOLOGIES LLC | $1.6M | 358,738 | Trimmed |
| 21 | Sofinnova Investments, Inc. | $1.5M | 321,692 | Added |
| 22 | Carlyle Group Inc. | $1.2M | 269,895 | Hold |
| 23 | DV EQUITIES, LLC | $1.1M | 240,963 | New |
| 24 | Affinity Asset Advisors, LLC | $1.1M | 240,963 | Hold |
| 25 | Seven Fleet Capital Management LP | $1.1M | 240,963 | New |