| 1 | RA CAPITAL MANAGEMENT, L.P. | $8.1M | 932,624 | Trimmed |
| 2 | ORBIMED ADVISORS LLC | $7.3M | 844,787 | Trimmed |
| 3 | FRANKLIN RESOURCES INC | $5.4M | 626,571 | Hold |
| 4 | CITADEL ADVISORS LLC | $4.0M | 466,248 | Added |
| 5 | VANGUARD GROUP INC | $3.4M | 399,119 | Added |
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.4M | 274,375 | Hold |
| 7 | RENAISSANCE TECHNOLOGIES LLC | $2.3M | 265,945 | Added |
| 8 | Stonepine Capital Management, LLC | $2.1M | 245,518 | Added |
| 9 | Alyeska Investment Group, L.P. | $1.8M | 203,799 | Hold |
| 10 | Schonfeld Strategic Advisors LLC | $1.7M | 195,514 | New |
| 11 | Carlyle Group Inc. | $1.6M | 184,295 | Hold |
| 12 | NEXTBio Capital Management LP | $1.4M | 157,827 | Hold |
| 13 | ACADIAN ASSET MANAGEMENT LLC | $1.1M | 124,832 | Added |
| 14 | TWO SIGMA INVESTMENTS, LP | $836,689 | 96,839 | Added |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $826,703 | 95,634 | Trimmed |
| 16 | DAFNA Capital Management LLC | $810,536 | 93,812 | Hold |
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | $742,686 | 85,959 | New |
| 18 | MARSHALL WACE, LLP | $686,775 | 79,488 | New |
| 19 | Trexquant Investment LP | $673,937 | 78,002 | Added |
| 20 | JANE STREET GROUP, LLC | $609,647 | 70,561 | Added |
| 21 | Burkehill Global Management, LP | $540,000 | 62,500 | Hold |
| 22 | BlackRock, Inc. | $536,769 | 62,126 | Added |
| 23 | REGENERON PHARMACEUTICALS, INC. | $522,819 | 60,511 | Hold |
| 24 | Rangeley Capital, LLC | $439,707 | 50,892 | Trimmed |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $347,760 | 40,250 | Trimmed |