| 1 | FMR LLC | $582.4M | 9.6M | Trimmed |
| 2 | BlackRock, Inc. | $454.1M | 7.5M | Added |
| 3 | Avoro Capital Advisors LLC | $348.7M | 5.8M | Hold |
| 4 | Polar Capital Holdings Plc | $275.9M | 4.6M | Added |
| 5 | Driehaus Capital Management LLC | $266.7M | 4.4M | Trimmed |
| 6 | Jupiter Topco LLC | $252.7M | 4.2M | New |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | $196.1M | 3.2M | Added |
| 8 | JPMORGAN CHASE & CO | $157.4M | 2.6M | Added |
| 9 | Capital International Investors | $142.5M | 2.4M | Trimmed |
| 10 | T. Rowe Price Investment Management, Inc. | $130.9M | 2.2M | Added |
| 11 | STATE STREET CORP | $118.9M | 2.0M | Added |
| 12 | TWO SIGMA INVESTMENTS, LP | $99.2M | 1.6M | Added |
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | $97.5M | 1.6M | Hold |
| 14 | Affinity Asset Advisors, LLC | $96.3M | 1.6M | Trimmed |
| 15 | WESTFIELD CAPITAL MANAGEMENT CO LP | $91.0M | 1.5M | Added |
| 16 | ALLIANCEBERNSTEIN L.P. | $90.8M | 1.6M | Added |
| 17 | CITADEL ADVISORS LLC | $87.4M | 1.4M | Trimmed |
| 18 | FRANKLIN RESOURCES INC | $86.8M | 1.4M | Added |
| 19 | WELLINGTON MANAGEMENT GROUP LLP | $86.0M | 1.4M | Trimmed |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | $82.7M | 1.4M | Added |
| 21 | Siren, L.L.C. | $79.6M | 1.3M | Hold |
| 22 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $77.9M | 1.3M | Trimmed |
| 23 | Pictet Asset Management Holding SA | $71.6M | 1.2M | Added |
| 24 | BRAIDWELL LP | $68.3M | 1.1M | Trimmed |
| 25 | VANGUARD GROUP INC | $61.7M | 1.0M | Added |