Who Owns SPYRE THERAPEUTICS INC (SYRE)? -- Institutional Holders (2026-06-30)
280 institutions reported holding $8.63B of SPYRE THERAPEUTICS INC (SYRE) in SEC 13F filings for 2026-06-30. Largest institutional holders: FMR LLC ($1.16B), BlackRock, Inc. ($577.7M), VANGUARD GROUP INC ($569.8M), PERCEPTIVE ADVISORS LLC ($383.5M), RTW INVESTMENTS, LP ($377.5M). Source: SEC Form 13F.
| Rank | Institution | Value | Shares | Change |
|---|
| 1 | FMR LLC | $1.16B | 13.0M | Added |
| 2 | BlackRock, Inc. | $577.7M | 6.5M | Added |
| 3 | VANGUARD GROUP INC | $569.8M | 6.4M | Added |
| 4 | PERCEPTIVE ADVISORS LLC | $383.5M | 4.3M | Added |
| 5 | RTW INVESTMENTS, LP | $377.5M | 4.3M | Added |
| 6 | Paradigm Biocapital Advisors LP | $341.0M | 3.8M | Added |
| 7 | STATE STREET CORP | $271.4M | 3.1M | Added |
| 8 | VR ADVISER, LLC | $265.0M | 3.0M | Trimmed |
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | $262.9M | 3.0M | Added |
| 10 | Driehaus Capital Management LLC | $248.5M | 2.8M | Added |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | $239.3M | 2.6M | Added |
| 12 | Capital World Investors | $205.6M | 2.3M | Added |
| 13 | Jupiter Topco LLC | $195.9M | 2.2M | New |
| 14 | TCG Crossover Management, LLC | $168.7M | 1.9M | Hold |
| 15 | TANG CAPITAL MANAGEMENT LLC | $168.0M | 1.9M | Hold |
| 16 | BANK OF AMERICA CORP /DE/ | $157.8M | 1.8M | Added |
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $152.9M | 1.7M | New |
| 18 | WELLINGTON MANAGEMENT GROUP LLP | $140.4M | 1.6M | Trimmed |
| 19 | GOLDMAN SACHS GROUP INC | $131.2M | 1.5M | Added |
| 20 | FRANKLIN RESOURCES INC | $130.8M | 1.5M | Added |
| 21 | Remedium Capital Partners, LLC | $130.0M | 1.5M | Added |
| 22 | Affinity Asset Advisors, LLC | $113.6M | 1.3M | Hold |
| 23 | JPMORGAN CHASE & CO | $98.9M | 1.1M | Added |
| 24 | Holocene Advisors, LP | $90.1M | 1.0M | New |
| 25 | MARSHALL WACE, LLP | $88.0M | 991,693 | Added |
Source: SEC Form 13F filings · as of 2026-06-30