| 1 | VANGUARD GROUP INC | $397.7M | 11.9M | Added |
| 2 | BlackRock, Inc. | $355.7M | 10.7M | Added |
| 3 | RTW INVESTMENTS, LP | $260.3M | 7.8M | Added |
| 4 | AQR CAPITAL MANAGEMENT LLC | $214.1M | 6.6M | Added |
| 5 | STATE STREET CORP | $205.6M | 6.2M | Added |
| 6 | TWO SIGMA INVESTMENTS, LP | $120.9M | 3.6M | Added |
| 7 | SANDS CAPITAL MANAGEMENT, LLC | $105.5M | 3.2M | Trimmed |
| 8 | JACOBS LEVY EQUITY MANAGEMENT, INC | $98.2M | 2.9M | Added |
| 9 | FRONTIER CAPITAL MANAGEMENT CO LLC | $95.1M | 2.8M | Added |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | $86.1M | 2.6M | Added |
| 11 | Sofinnova Investments, Inc. | $74.0M | 2.2M | Trimmed |
| 12 | Bellevue Group AG | $66.2M | 2.0M | Trimmed |
| 13 | D. E. Shaw & Co., Inc. | $57.8M | 1.7M | Added |
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $52.8M | 1.6M | Added |
| 15 | GW&K Investment Management, LLC | $49.5M | 1.5M | Trimmed |
| 16 | MPM BIOIMPACT LLC | $47.4M | 1.4M | New |
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | $45.3M | 1.4M | Added |
| 18 | MORGAN STANLEY | $44.2M | 1.3M | Trimmed |
| 19 | Caption Management, LLC | $42.1M | 1.3M | Added |
| 20 | WELLINGTON MANAGEMENT GROUP LLP | $41.8M | 1.3M | Trimmed |
| 21 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | $41.5M | 1.2M | Trimmed |
| 22 | BANK OF AMERICA CORP /DE/ | $38.3M | 1.1M | Added |
| 23 | Candriam S.C.A. | $33.4M | 1.0M | Trimmed |
| 24 | Rock Springs Capital Management LP | $32.3M | 967,855 | Trimmed |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $32.3M | 965,871 | Trimmed |