| 1 | ORBIMED ADVISORS LLC | $73.2M | 13.7M | Added |
| 2 | BAKER BROS. ADVISORS LP | $54.0M | 10.1M | Hold |
| 3 | RA CAPITAL MANAGEMENT, L.P. | $34.5M | 6.5M | New |
| 4 | Soleus Capital Management, L.P. | $18.0M | 3.4M | New |
| 5 | VANGUARD GROUP INC | $13.3M | 2.5M | Added |
| 6 | Kynam Capital Management, LP | $12.9M | 2.4M | Added |
| 7 | BlackRock, Inc. | $9.6M | 1.8M | Added |
| 8 | SPHERA FUNDS MANAGEMENT LTD. | $5.4M | 1.0M | Added |
| 9 | TWO SIGMA INVESTMENTS, LP | $5.3M | 993,369 | Added |
| 10 | ADAR1 Capital Management, LLC | $4.8M | 900,900 | Added |
| 11 | MILLENNIUM MANAGEMENT LLC | $4.5M | 844,993 | Added |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | $4.5M | 841,862 | Added |
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $4.1M | 766,095 | New |
| 14 | ACADIAN ASSET MANAGEMENT LLC | $3.3M | 611,359 | Added |
| 15 | MORGAN STANLEY | $2.7M | 503,860 | Added |
| 16 | STATE STREET CORP | $2.3M | 428,787 | Added |
| 17 | UBS Group AG | $1.7M | 318,797 | Added |
| 18 | RENAISSANCE TECHNOLOGIES LLC | $1.5M | 281,200 | Added |
| 19 | NORTHERN TRUST CORP | $1.3M | 240,599 | Added |
| 20 | MARSHALL WACE, LLP | $1.0M | 190,692 | Trimmed |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $931,151 | 174,700 | Trimmed |
| 22 | Connor, Clark & Lunn Investment Management Ltd. | $669,480 | 125,606 | Added |
| 23 | GOLDMAN SACHS GROUP INC | $644,045 | 120,834 | Trimmed |
| 24 | JANE STREET GROUP, LLC | $448,786 | 84,200 | Trimmed |
| 25 | Hillsdale Investment Management Inc. | $433,862 | 81,400 | New |