| 1 | Jupiter Topco LLC | $121.7M | 1.3M | New |
| 2 | RA CAPITAL MANAGEMENT, L.P. | $61.8M | 667,207 | Hold |
| 3 | BlackRock, Inc. | $32.3M | 348,819 | Added |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | $30.0M | 323,745 | Hold |
| 5 | Saturn V Capital Management LP | $28.9M | 311,976 | Trimmed |
| 6 | VANGUARD GROUP INC | $26.7M | 288,360 | Trimmed |
| 7 | Siren, L.L.C. | $25.0M | 270,118 | Hold |
| 8 | ADAR1 Capital Management, LLC | $20.1M | 217,595 | Trimmed |
| 9 | Polar Capital Holdings Plc | $19.9M | 214,469 | Trimmed |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $19.4M | 209,195 | Trimmed |
| 11 | TCG Crossover Management, LLC | $18.8M | 203,327 | Added |
| 12 | WELLINGTON MANAGEMENT GROUP LLP | $14.7M | 158,437 | Trimmed |
| 13 | ORBIMED ADVISORS LLC | $14.6M | 157,423 | New |
| 14 | Candriam S.C.A. | $13.3M | 143,339 | New |
| 15 | Balyasny Asset Management L.P. | $12.5M | 134,543 | Trimmed |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | $10.4M | 112,578 | Added |
| 17 | Alyeska Investment Group, L.P. | $9.3M | 100,000 | Hold |
| 18 | STATE STREET CORP | $8.6M | 92,551 | Added |
| 19 | Vivo Capital, LLC | $8.4M | 90,500 | Hold |
| 20 | Driehaus Capital Management LLC | $7.8M | 84,040 | Added |
| 21 | Bank of New York Mellon Corp | $7.1M | 76,942 | Trimmed |
| 22 | Vestal Point Capital, LP | $7.0M | 75,727 | Added |
| 23 | Longaeva Partners L.P. | $5.2M | 55,834 | New |
| 24 | NEUBERGER BERMAN GROUP LLC | $5.1M | 55,194 | Added |
| 25 | MILLENNIUM MANAGEMENT LLC | $4.7M | 50,311 | Trimmed |