| 1 | Frazier Life Sciences Management, L.P. | $367.2M | 6.7M | Hold |
| 2 | FMR LLC | $293.8M | 5.3M | Added |
| 3 | WELLINGTON MANAGEMENT GROUP LLP | $274.8M | 5.0M | Added |
| 4 | NEA Management Company, LLC | $199.5M | 3.6M | Hold |
| 5 | ORBIMED ADVISORS LLC | $189.3M | 3.4M | Trimmed |
| 6 | BlackRock, Inc. | $183.5M | 3.3M | Added |
| 7 | Paradigm Biocapital Advisors LP | $138.4M | 2.5M | New |
| 8 | NVP ASSOCIATES, LLC | $117.9M | 2.1M | Hold |
| 9 | VANGUARD GROUP INC | $114.0M | 2.1M | Added |
| 10 | Deep Track Capital, LP | $95.6M | 1.7M | Trimmed |
| 11 | Polar Capital Holdings Plc | $88.8M | 1.6M | Trimmed |
| 12 | Aaron Wealth Advisors LLC | $64.5M | 1.2M | Trimmed |
| 13 | Driehaus Capital Management LLC | $58.3M | 1.1M | Added |
| 14 | Kynam Capital Management, LP | $51.6M | 934,799 | Hold |
| 15 | Woodline Partners LP | $49.7M | 900,092 | Added |
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | $48.2M | 873,492 | Trimmed |
| 17 | STATE STREET CORP | $47.7M | 864,466 | Added |
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | $45.0M | 814,807 | Trimmed |
| 19 | Parkman Healthcare Partners LLC | $44.2M | 800,173 | Added |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | $42.7M | 773,072 | Added |
| 21 | BRAIDWELL LP | $39.2M | 710,880 | Trimmed |
| 22 | TCG Crossover Management, LLC | $35.9M | 650,000 | Hold |
| 23 | Cormorant Asset Management, LP | $30.4M | 550,000 | Trimmed |
| 24 | Soleus Capital Management, L.P. | $28.4M | 515,279 | Added |
| 25 | GOLDMAN SACHS GROUP INC | $25.3M | 459,005 | Added |