| 1 | BlackRock, Inc. | $115.3M | 10.5M | Added |
| 2 | SUVRETTA CAPITAL MANAGEMENT, LLC | $94.1M | 8.6M | Hold |
| 3 | BVF INC/IL | $92.7M | 8.4M | Hold |
| 4 | VANGUARD GROUP INC | $65.9M | 6.0M | Added |
| 5 | STATE STREET CORP | $58.5M | 5.3M | Added |
| 6 | ARMISTICE CAPITAL, LLC | $40.3M | 3.7M | Trimmed |
| 7 | AQR CAPITAL MANAGEMENT LLC | $34.3M | 3.1M | Added |
| 8 | GOLDMAN SACHS GROUP INC | $24.8M | 2.3M | Added |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | $24.5M | 2.2M | Added |
| 10 | ALETHEA CAPITAL MANAGEMENT, LLC | $23.8M | 2.2M | Added |
| 11 | Prosight Management, LP | $22.2M | 2.0M | Trimmed |
| 12 | Deep Track Capital, LP | $21.7M | 2.0M | Trimmed |
| 13 | RENAISSANCE TECHNOLOGIES LLC | $18.3M | 1.7M | Added |
| 14 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $15.5M | 1.4M | New |
| 15 | NAN FUNG TRINITY (HK) LTD | $12.9M | 1.2M | Added |
| 16 | Qube Research & Technologies Ltd | $12.8M | 1.2M | Trimmed |
| 17 | DIMENSIONAL FUND ADVISORS LP | $12.8M | 1.2M | Trimmed |
| 18 | BANK OF AMERICA CORP /DE/ | $12.7M | 1.2M | Trimmed |
| 19 | MORGAN STANLEY | $12.7M | 1.2M | Trimmed |
| 20 | Connor, Clark & Lunn Investment Management Ltd. | $10.9M | 996,114 | Added |
| 21 | UBS Group AG | $10.6M | 964,636 | Trimmed |
| 22 | JACOBS LEVY EQUITY MANAGEMENT, INC | $10.4M | 948,974 | Added |
| 23 | NORTHERN TRUST CORP | $9.1M | 831,160 | Added |
| 24 | MILLENNIUM MANAGEMENT LLC | $7.8M | 711,332 | Trimmed |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7.4M | 676,400 | Trimmed |