| 1 | FMR LLC | $445.8M | 7.0M | Added |
| 2 | Rubric Capital Management LP | $255.8M | 4.0M | Added |
| 3 | VANGUARD GROUP INC | $216.2M | 3.4M | Added |
| 4 | BAKER BROS. ADVISORS LP | $181.3M | 2.8M | Added |
| 5 | BlackRock, Inc. | $175.2M | 2.7M | Added |
| 6 | TANG CAPITAL MANAGEMENT LLC | $144.5M | 2.3M | Hold |
| 7 | MORGAN STANLEY | $64.7M | 1.0M | Added |
| 8 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $61.2M | 957,514 | Added |
| 9 | Spruce Street Capital LP | $58.7M | 918,070 | Added |
| 10 | DIMENSIONAL FUND ADVISORS LP | $55.9M | 874,786 | Added |
| 11 | Invesco Ltd. | $49.4M | 772,806 | Added |
| 12 | Driehaus Capital Management LLC | $45.9M | 718,199 | Added |
| 13 | STATE STREET CORP | $45.0M | 704,194 | Added |
| 14 | ACADIAN ASSET MANAGEMENT LLC | $43.4M | 679,083 | Trimmed |
| 15 | Point72 Asset Management, L.P. | $42.2M | 659,493 | Added |
| 16 | RICE HALL JAMES & ASSOCIATES, LLC | $40.0M | 624,928 | Added |
| 17 | Pictet Asset Management Holding SA | $38.9M | 608,650 | Trimmed |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | $38.6M | 604,180 | Added |
| 19 | Jupiter Topco LLC | $37.5M | 586,177 | New |
| 20 | Connor, Clark & Lunn Investment Management Ltd. | $36.6M | 572,598 | Trimmed |
| 21 | D. E. Shaw & Co., Inc. | $36.4M | 569,756 | Trimmed |
| 22 | TWO SIGMA INVESTMENTS, LP | $35.9M | 561,480 | Added |
| 23 | VICTORY CAPITAL MANAGEMENT INC | $32.3M | 504,853 | Trimmed |
| 24 | SG Americas Securities, LLC | $32.2M | 504,001 | Trimmed |
| 25 | BNP PARIBAS FINANCIAL MARKETS | $28.0M | 437,192 | Trimmed |