| 1 | T. Rowe Price Investment Management, Inc. | $417.0M | 19.7M | Added |
| 2 | FMR LLC | $360.0M | 17.0M | Added |
| 3 | BlackRock, Inc. | $186.6M | 8.8M | Added |
| 4 | VANGUARD GROUP INC | $144.0M | 6.8M | Added |
| 5 | STATE STREET CORP | $116.4M | 5.5M | Added |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | $110.4M | 5.2M | Added |
| 7 | Redmile Group, LLC | $104.1M | 4.9M | Trimmed |
| 8 | PRIMECAP MANAGEMENT CO/CA/ | $97.1M | 4.6M | Trimmed |
| 9 | Driehaus Capital Management LLC | $92.1M | 4.3M | Added |
| 10 | ENAVATE SCIENCES GP, LLC | $76.6M | 3.6M | Hold |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | $58.4M | 2.8M | Added |
| 12 | MORGAN STANLEY | $51.0M | 2.4M | Trimmed |
| 13 | SILVERARC CAPITAL MANAGEMENT, LLC | $42.7M | 2.0M | Added |
| 14 | JPMORGAN CHASE & CO | $39.0M | 1.8M | Trimmed |
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | $37.6M | 1.8M | Trimmed |
| 16 | Sofinnova Investments, Inc. | $36.5M | 1.7M | Added |
| 17 | READYSTATE ASSET MANAGEMENT LP | $34.0M | 1.6M | Added |
| 18 | GOLDMAN SACHS GROUP INC | $32.0M | 1.5M | Added |
| 19 | PRINCIPAL FINANCIAL GROUP INC | $28.6M | 1.3M | Trimmed |
| 20 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $26.5M | 1.3M | Added |
| 21 | Woodline Partners LP | $21.2M | 1.0M | Trimmed |
| 22 | NORTHERN TRUST CORP | $20.5M | 968,346 | Added |
| 23 | Sixth Street Partners Management Company, L.P. | $18.8M | 886,193 | New |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $18.8M | 886,193 | Added |
| 25 | MetLife Investment Management, LLC | $18.2M | 859,076 | Added |