| 1 | WELLINGTON MANAGEMENT GROUP LLP | $202.3M | 5.7M | Trimmed |
| 2 | RTW INVESTMENTS, LP | $154.6M | 4.9M | Hold |
| 3 | FMR LLC | $136.8M | 4.3M | Trimmed |
| 4 | PRIMECAP MANAGEMENT CO/CA/ | $115.5M | 3.6M | Trimmed |
| 5 | Bellevue Group AG | $88.5M | 2.8M | Trimmed |
| 6 | TANG CAPITAL MANAGEMENT LLC | $84.1M | 2.6M | Hold |
| 7 | Linden Advisors LP | $71.9M | 0 | Trimmed |
| 8 | Context Capital Management, LLC | $63.7M | 0 | Trimmed |
| 9 | Vestal Point Capital, LP | $57.1M | 1.8M | Trimmed |
| 10 | TWO SIGMA INVESTMENTS, LP | $52.4M | 1.6M | Added |
| 11 | MILLENNIUM MANAGEMENT LLC | $50.7M | 1.6M | Added |
| 12 | ARMISTICE CAPITAL, LLC | $45.3M | 1.4M | Added |
| 13 | Caligan Partners LP | $43.9M | 1.4M | New |
| 14 | Kynam Capital Management, LP | $43.7M | 1.4M | Added |
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | $41.2M | 831,068 | Trimmed |
| 16 | BVF INC/IL | $41.1M | 1.3M | Hold |
| 17 | CAMDEN ASSET MANAGEMENT L P /CA | $40.7M | 0 | Added |
| 18 | BlackRock, Inc. | $39.4M | 1.0M | Added |
| 19 | ACADIAN ASSET MANAGEMENT LLC | $38.4M | 1.2M | Added |
| 20 | Trails Edge Capital Partners, LP | $33.8M | 1.1M | Added |
| 21 | Point72 Asset Management, L.P. | $31.4M | 990,280 | Trimmed |
| 22 | DEERFIELD MANAGEMENT COMPANY, L.P. | $27.1M | 0 | Hold |
| 23 | Jupiter Topco LLC | $22.5M | 709,022 | New |
| 24 | CITADEL ADVISORS LLC | $20.7M | 651,961 | Added |
| 25 | Logos Global Management LP | $19.1M | 600,000 | Trimmed |