| 1 | Soleus Capital Management, L.P. | $37.9M | 7.3M | Hold |
| 2 | MORGAN STANLEY | $17.3M | 3.3M | Trimmed |
| 3 | Rock Springs Capital Management LP | $7.2M | 1.4M | Added |
| 4 | FLAX POND CAPITAL, LLC | $6.8M | 1.5M | Added |
| 5 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2.4M | 470,994 | Added |
| 6 | Bruce & Co., Inc. | $2.3M | 438,652 | Hold |
| 7 | JANE STREET GROUP, LLC | $1.8M | 343,300 | Added |
| 8 | CITADEL ADVISORS LLC | $1.3M | 256,083 | Added |
| 9 | Parkman Healthcare Partners LLC | $802,030 | 154,832 | Hold |
| 10 | ESSEX INVESTMENT MANAGEMENT CO LLC | $756,306 | 146,005 | New |
| 11 | CAHILL FINANCIAL ADVISORS INC | $699,093 | 134,960 | Hold |
| 12 | US BANCORP \DE\ | $634,550 | 122,500 | Added |
| 13 | UBS Group AG | $613,286 | 118,395 | Trimmed |
| 14 | Sage Mountain Advisors LLC | $518,000 | 100,000 | Hold |
| 15 | Leonteq Securities AG | $492,048 | 94,990 | Hold |
| 16 | Summit Trail Advisors, LLC | $426,516 | 82,339 | Trimmed |
| 17 | Cetera Investment Advisers | $383,382 | 74,012 | Hold |
| 18 | IMC-Chicago, LLC | $382,284 | 73,800 | Added |
| 19 | COMMONWEALTH EQUITY SERVICES, LLC | $358,250 | 69,160 | Hold |
| 20 | Legato Capital Management LLC | $250,033 | 48,269 | New |
| 21 | OSAIC HOLDINGS, INC. | $221,186 | 42,700 | Hold |
| 22 | Schonfeld Strategic Advisors LLC | $216,161 | 41,730 | Added |
| 23 | Manatuck Hill Partners, LLC | $142,952 | 27,597 | Hold |
| 24 | INTREPID FAMILY OFFICE LLC | $129,500 | 25,000 | Hold |
| 25 | SmartHarvest Portfolios, LLC | $123,973 | 23,933 | Added |