| 1 | ARK Investment Management LLC | $516.0M | 9.5M | Trimmed |
| 2 | BlackRock, Inc. | $455.4M | 8.3M | Added |
| 3 | Orbis Allan Gray Ltd | $297.2M | 5.4M | Trimmed |
| 4 | Capital World Investors | $259.0M | 4.7M | Added |
| 5 | STATE STREET CORP | $235.7M | 4.3M | Added |
| 6 | GSK plc | $175.7M | 3.2M | Hold |
| 7 | VANGUARD GROUP INC | $138.9M | 2.5M | Added |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | $136.9M | 2.5M | Added |
| 9 | T. Rowe Price Investment Management, Inc. | $112.0M | 2.1M | Trimmed |
| 10 | SR One Capital Management, LP | $111.2M | 2.0M | Hold |
| 11 | TWO SIGMA INVESTMENTS, LP | $108.5M | 2.0M | Added |
| 12 | FMR LLC | $104.1M | 1.9M | Trimmed |
| 13 | Sumitomo Mitsui Trust Group, Inc. | $93.8M | 1.7M | Trimmed |
| 14 | Amova Asset Management Americas, Inc. | $93.8M | 1.7M | Trimmed |
| 15 | EcoR1 Capital, LLC | $75.8M | 1.4M | Hold |
| 16 | UBS Group AG | $72.0M | 1.3M | Trimmed |
| 17 | Capital International Investors | $69.2M | 1.3M | Added |
| 18 | BANK OF AMERICA CORP /DE/ | $63.0M | 1.2M | Added |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $59.5M | 1.1M | Trimmed |
| 20 | NEA Management Company, LLC | $57.7M | 1.1M | Hold |
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $57.7M | 1.1M | Added |
| 22 | Sixth Street Partners Management Company, L.P. | $57.7M | 1.1M | New |
| 23 | CITADEL ADVISORS LLC | $55.2M | 1.0M | Trimmed |
| 24 | D. E. Shaw & Co., Inc. | $55.0M | 1.0M | Added |
| 25 | MORGAN STANLEY | $48.0M | 879,949 | Added |