| 1 | FMR LLC | $592.7M | 15.8M | Added |
| 2 | VANGUARD GROUP INC | $392.2M | 10.5M | Added |
| 3 | BlackRock, Inc. | $365.2M | 9.8M | Added |
| 4 | FARALLON CAPITAL MANAGEMENT LLC | $336.4M | 9.0M | Added |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | $266.8M | 7.1M | Trimmed |
| 6 | Driehaus Capital Management LLC | $241.9M | 6.5M | Added |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | $232.5M | 6.2M | Added |
| 8 | Jupiter Topco LLC | $170.5M | 4.6M | New |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | $102.1M | 2.7M | Added |
| 10 | STATE STREET CORP | $100.6M | 2.7M | Added |
| 11 | Bellevue Group AG | $98.0M | 2.6M | Trimmed |
| 12 | BAKER BROS. ADVISORS LP | $88.0M | 2.4M | Hold |
| 13 | Polar Capital Holdings Plc | $85.1M | 2.3M | New |
| 14 | Pictet Asset Management Holding SA | $77.6M | 2.1M | Added |
| 15 | T. Rowe Price Investment Management, Inc. | $75.2M | 2.0M | Added |
| 16 | GW&K Investment Management, LLC | $64.8M | 1.7M | Added |
| 17 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $62.8M | 1.7M | Trimmed |
| 18 | Siren, L.L.C. | $53.2M | 1.4M | Trimmed |
| 19 | First Light Asset Management, LLC | $50.9M | 1.4M | Added |
| 20 | JPMORGAN CHASE & CO | $50.6M | 1.4M | Added |
| 21 | MORGAN STANLEY | $50.1M | 1.3M | Added |
| 22 | BANK OF AMERICA CORP /DE/ | $49.9M | 1.3M | Added |
| 23 | NOVO HOLDINGS A/S | $49.4M | 1.3M | Trimmed |
| 24 | DIMENSIONAL FUND ADVISORS LP | $47.5M | 1.3M | Added |
| 25 | AMERICAN CENTURY COMPANIES INC | $47.2M | 1.3M | Added |