| 1 | BAKER BROS. ADVISORS LP | $897.3M | 7.9M | Hold |
| 2 | Avoro Capital Advisors LLC | $355.7M | 3.4M | Trimmed |
| 3 | Linden Advisors LP | $352.5M | 0 | Added |
| 4 | PERCEPTIVE ADVISORS LLC | $349.1M | 3.2M | Added |
| 5 | RTW INVESTMENTS, LP | $345.8M | 3.3M | Added |
| 6 | BlackRock, Inc. | $330.6M | 3.0M | Added |
| 7 | VANGUARD GROUP INC | $268.4M | 2.6M | Added |
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | $265.6M | 1.5M | Added |
| 9 | STATE STREET CORP | $204.6M | 2.0M | Added |
| 10 | NEA Management Company, LLC | $179.0M | 1.7M | Trimmed |
| 11 | Soleus Capital Management, L.P. | $178.3M | 1.7M | Added |
| 12 | BANK OF AMERICA CORP /DE/ | $153.9M | 1.5M | Added |
| 13 | MORGAN STANLEY | $142.5M | 1.3M | Added |
| 14 | TANG CAPITAL MANAGEMENT LLC | $137.5M | 1.3M | Added |
| 15 | TORONTO DOMINION BANK | $132.3M | 1.3M | Added |
| 16 | Voya Investment Management LLC | $120.8M | 278,827 | Added |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | $116.3M | 1.1M | Added |
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | $107.3M | 1.0M | Trimmed |
| 19 | WELLINGTON MANAGEMENT GROUP LLP | $94.8M | 906,595 | Added |
| 20 | GOLDMAN SACHS GROUP INC | $92.0M | 870,449 | Added |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $89.5M | 855,878 | Added |
| 22 | Point72 Asset Management, L.P. | $68.1M | 650,916 | Added |
| 23 | Hood River Capital Management LLC | $65.7M | 628,411 | New |
| 24 | FMR LLC | $63.9M | 548,983 | Added |
| 25 | ALLIANCEBERNSTEIN L.P. | $60.6M | 530,922 | Added |