| 1 | ARCH Venture Management, LLC | $6.7M | 2.7M | New |
| 2 | FMR LLC | $6.5M | 2.6M | Trimmed |
| 3 | TANG CAPITAL MANAGEMENT LLC | $6.4M | 2.6M | New |
| 4 | ADAR1 Capital Management, LLC | $4.9M | 2.0M | New |
| 5 | Cormorant Asset Management, LP | $2.5M | 1.0M | New |
| 6 | VANGUARD GROUP INC | $1.7M | 680,059 | Added |
| 7 | WELLINGTON MANAGEMENT GROUP LLP | $1.4M | 556,233 | Hold |
| 8 | MILLENNIUM MANAGEMENT LLC | $1.2M | 478,639 | Added |
| 9 | RENAISSANCE TECHNOLOGIES LLC | $1.2M | 471,570 | Added |
| 10 | Alyeska Investment Group, L.P. | $750,000 | 300,000 | Hold |
| 11 | Affinity Asset Advisors, LLC | $625,000 | 250,000 | New |
| 12 | RBF Capital, LLC | $500,000 | 200,000 | Hold |
| 13 | Ensign Peak Advisors, Inc | $399,588 | 159,835 | Trimmed |
| 14 | Stonepine Capital Management, LLC | $386,488 | 154,595 | Trimmed |
| 15 | ACADIAN ASSET MANAGEMENT LLC | $365,000 | 146,757 | Added |
| 16 | CITADEL ADVISORS LLC | $362,623 | 145,049 | Trimmed |
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | $320,000 | 128,000 | Added |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | $291,839 | 116,736 | Trimmed |
| 19 | HRT FINANCIAL LP | $290,000 | 116,288 | New |
| 20 | BlackRock, Inc. | $221,239 | 88,495 | Added |
| 21 | PRELUDE CAPITAL MANAGEMENT, LLC | $209,995 | 83,998 | New |
| 22 | Rangeley Capital, LLC | $185,000 | 74,000 | New |
| 23 | GSA CAPITAL PARTNERS LLP | $181,000 | 72,353 | Trimmed |
| 24 | JANE STREET GROUP, LLC | $160,807 | 64,323 | New |
| 25 | SUPERSTRING CAPITAL MANAGEMENT LP | $138,390 | 55,356 | New |