| 1 | Darwin Global Management, Ltd. | $456.6M | 3.1M | Added |
| 2 | Paradigm Biocapital Advisors LP | $189.8M | 1.2M | Added |
| 3 | RTW INVESTMENTS, LP | $110.2M | 715,332 | Hold |
| 4 | MILLENNIUM MANAGEMENT LLC | $76.2M | 494,564 | Trimmed |
| 5 | MAVERICK CAPITAL LTD | $61.0M | 396,311 | New |
| 6 | EVENTIDE ASSET MANAGEMENT, LLC | $60.2M | 390,829 | Added |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | $55.0M | 357,199 | Added |
| 8 | Holocene Advisors, LP | $38.7M | 251,035 | Trimmed |
| 9 | Logos Global Management LP | $38.5M | 250,000 | New |
| 10 | MORGAN STANLEY | $36.2M | 235,071 | Added |
| 11 | UBS Group AG | $34.6M | 224,989 | Trimmed |
| 12 | CITADEL ADVISORS LLC | $28.7M | 186,168 | Added |
| 13 | GOLDMAN SACHS GROUP INC | $25.6M | 166,188 | Added |
| 14 | Affinity Asset Advisors, LLC | $25.4M | 165,000 | Added |
| 15 | MPM BIOIMPACT LLC | $21.1M | 137,208 | Added |
| 16 | BANK OF AMERICA CORP /DE/ | $19.2M | 124,783 | Added |
| 17 | Patient Square Capital LP | $16.9M | 110,000 | Trimmed |
| 18 | Duquesne Family Office LLC | $16.3M | 106,100 | Hold |
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | $16.3M | 105,859 | Trimmed |
| 20 | JANE STREET GROUP, LLC | $10.1M | 65,801 | Added |
| 21 | BNP PARIBAS FINANCIAL MARKETS | $8.8M | 57,125 | Added |
| 22 | RENAISSANCE TECHNOLOGIES LLC | $8.6M | 55,763 | Added |
| 23 | Point72 Asset Management, L.P. | $7.9M | 51,186 | New |
| 24 | Soleus Capital Management, L.P. | $7.8M | 50,524 | New |
| 25 | Trexquant Investment LP | $7.6M | 49,516 | Added |