| 1 | FMR LLC | $432.7M | 12.6M | Added |
| 2 | VANGUARD GROUP INC | $356.3M | 10.4M | Added |
| 3 | FARALLON CAPITAL MANAGEMENT LLC | $351.3M | 10.2M | Added |
| 4 | ARK Investment Management LLC | $351.3M | 10.2M | Trimmed |
| 5 | BlackRock, Inc. | $308.8M | 9.0M | Added |
| 6 | STATE STREET CORP | $200.0M | 5.8M | Added |
| 7 | ARCH Venture Management, LLC | $155.8M | 4.5M | Hold |
| 8 | Sumitomo Mitsui Trust Group, Inc. | $118.6M | 3.5M | Trimmed |
| 9 | Amova Asset Management Americas, Inc. | $118.5M | 3.5M | Trimmed |
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | $117.2M | 3.4M | Added |
| 11 | Kynam Capital Management, LP | $97.5M | 2.8M | Trimmed |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | $89.1M | 2.6M | Added |
| 13 | DIMENSIONAL FUND ADVISORS LP | $76.4M | 2.2M | Added |
| 14 | MORGAN STANLEY | $67.0M | 2.0M | Added |
| 15 | Contrarius Group Holdings Ltd | $55.4M | 1.6M | Added |
| 16 | UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | $53.3M | 1.6M | Trimmed |
| 17 | TWO SIGMA INVESTMENTS, LP | $47.6M | 1.4M | Added |
| 18 | Casdin Capital, LLC | $46.3M | 1.4M | Hold |
| 19 | GOLDMAN SACHS GROUP INC | $45.0M | 1.3M | Added |
| 20 | Redmile Group, LLC | $40.0M | 1.2M | Trimmed |
| 21 | BNP PARIBAS FINANCIAL MARKETS | $36.6M | 1.1M | Added |
| 22 | Deep Track Capital, LP | $34.3M | 1.0M | Added |
| 23 | NORTHERN TRUST CORP | $32.0M | 933,481 | Added |
| 24 | Sixth Street Partners Management Company, L.P. | $30.4M | 885,902 | New |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $30.4M | 885,902 | Added |