| 1 | RA CAPITAL MANAGEMENT, L.P. | $174.2M | 18.0M | Added |
| 2 | VIKING GLOBAL INVESTORS LP | $25.3M | 2.6M | New |
| 3 | Blackstone Inc. | $23.3M | 2.4M | New |
| 4 | 5AM Venture Management, LLC | $22.8M | 2.4M | Hold |
| 5 | VR ADVISER, LLC | $19.8M | 2.0M | Added |
| 6 | FRANKLIN RESOURCES INC | $19.4M | 2.0M | Added |
| 7 | Caligan Partners LP | $16.8M | 1.7M | New |
| 8 | VANGUARD GROUP INC | $11.4M | 1.2M | Added |
| 9 | SAMSARA BIOCAPITAL, LLC | $9.3M | 954,861 | New |
| 10 | Blue Owl Capital Holdings LP | $8.5M | 874,542 | New |
| 11 | Propel Bio Management, LLC | $6.8M | 696,436 | Added |
| 12 | BlackRock, Inc. | $6.7M | 694,726 | Added |
| 13 | CITADEL ADVISORS LLC | $5.9M | 609,376 | Added |
| 14 | SILVERARC CAPITAL MANAGEMENT, LLC | $5.1M | 525,000 | New |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | $3.4M | 353,845 | Added |
| 16 | BOOTHBAY FUND MANAGEMENT, LLC | $3.0M | 314,375 | New |
| 17 | Nantahala Capital Management, LLC | $2.9M | 300,000 | New |
| 18 | Revelation Capital Management, LLC | $2.9M | 299,311 | Hold |
| 19 | Alyeska Investment Group, L.P. | $2.7M | 273,615 | Added |
| 20 | ACUTA CAPITAL PARTNERS, LLC | $2.5M | 260,416 | New |
| 21 | KVP Capital Advisors, LP | $1.9M | 200,000 | New |
| 22 | WELLINGTON MANAGEMENT GROUP LLP | $1.9M | 194,108 | Hold |
| 23 | UBS Group AG | $1.8M | 184,020 | Added |
| 24 | SEVEN GRAND MANAGERS, LLC | $1.7M | 175,000 | New |
| 25 | STATE STREET CORP | $1.6M | 165,764 | Added |