| 1 | BVF INC/IL | $47.2M | 19.8M | Hold |
| 2 | WELLS FARGO & COMPANY/MN | $2.4M | 1.0M | Trimmed |
| 3 | RENAISSANCE TECHNOLOGIES LLC | $2.0M | 840,127 | Added |
| 4 | MILLENNIUM MANAGEMENT LLC | $1.8M | 773,594 | Trimmed |
| 5 | BlackRock, Inc. | $1.2M | 519,274 | Trimmed |
| 6 | DIMENSIONAL FUND ADVISORS LP | $812,145 | 340,082 | Trimmed |
| 7 | CITADEL ADVISORS LLC | $603,107 | 253,406 | Trimmed |
| 8 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $554,428 | 232,953 | Trimmed |
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $378,584 | 159,069 | Added |
| 10 | MORGAN STANLEY | $313,720 | 131,815 | Added |
| 11 | TWO SIGMA INVESTMENTS, LP | $244,723 | 102,825 | Added |
| 12 | Qube Research & Technologies Ltd | $219,795 | 92,351 | New |
| 13 | UBS Group AG | $203,762 | 85,614 | Trimmed |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | $147,212 | 61,854 | Trimmed |
| 15 | Jump Financial, LLC | $57,272 | 24,064 | Added |
| 16 | JANE STREET GROUP, LLC | $46,350 | 19,475 | Trimmed |
| 17 | Verdad Advisers, LP | $38,794 | 16,300 | New |
| 18 | China Universal Asset Management Co., Ltd. | $38,549 | 16,197 | Trimmed |
| 19 | GOLDMAN SACHS GROUP INC | $34,503 | 14,497 | Trimmed |
| 20 | Quadrature Capital Ltd | $30,919 | 12,991 | New |
| 21 | SG Americas Securities, LLC | $25,000 | 10,327 | New |
| 22 | AXQ CAPITAL, LP | $24,747 | 10,398 | New |
| 23 | Quinn Opportunity Partners LLC | $24,038 | 10,100 | Hold |
| 24 | Silverberg Bernstein Capital Management LLC | $23,800 | 10,000 | Hold |
| 25 | EFG International AG | $23,562 | 9,900 | Hold |