| 1 | Nantahala Capital Management, LLC | $38.0M | 6.2M | Added |
| 2 | BlackRock, Inc. | $20.7M | 3.4M | Added |
| 3 | Cable Car Capital, LP | $18.6M | 3.0M | Hold |
| 4 | AIGH Capital Management LLC | $18.5M | 3.0M | Trimmed |
| 5 | VANGUARD GROUP INC | $17.7M | 2.9M | Added |
| 6 | OneDigital Investment Advisors LLC | $10.2M | 1.7M | New |
| 7 | AWM Investment Company, Inc. | $9.2M | 1.5M | Added |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | $7.8M | 1.3M | Added |
| 9 | KENNEDY CAPITAL MANAGEMENT LLC | $7.7M | 1.2M | Trimmed |
| 10 | GOLDMAN SACHS GROUP INC | $7.6M | 1.2M | Added |
| 11 | STATE STREET CORP | $6.4M | 1.0M | Added |
| 12 | Propel Bio Management, LLC | $6.1M | 983,070 | Trimmed |
| 13 | NAN FUNG TRINITY (HK) LTD | $5.9M | 956,770 | Hold |
| 14 | Diametric Capital, LP | $4.7M | 755,021 | Added |
| 15 | J. Goldman & Co LP | $4.2M | 678,173 | Added |
| 16 | SILVERARC CAPITAL MANAGEMENT, LLC | $3.8M | 610,407 | Trimmed |
| 17 | Rubric Capital Management LP | $3.8M | 608,771 | New |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.7M | 603,377 | Trimmed |
| 19 | Stonepine Capital Management, LLC | $3.4M | 557,284 | Trimmed |
| 20 | NORTHERN TRUST CORP | $3.4M | 552,630 | Added |
| 21 | CITIGROUP INC | $3.4M | 548,300 | Added |
| 22 | SUVRETTA CAPITAL MANAGEMENT, LLC | $3.1M | 500,000 | Trimmed |
| 23 | NATIONAL BANK OF CANADA /FI/ | $3.1M | 500,000 | Hold |
| 24 | Knoll Capital Management, LLC | $3.0M | 485,515 | Hold |
| 25 | CITADEL ADVISORS LLC | $2.8M | 454,401 | Added |